Omnicef for Children : Uses, Side Effects, Interactions, Dosage

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Cefdinir is not appreciably metabolized. Activity is primarily due to parent drug. Cefdinir is eliminated principally via renal excretion with a mean plasma elimination half-life (t½) of 1.7 (± 0.6) hours. In healthy subjects with normal renal function, renal clearance is 2.0 (± 1.0) mL/min/kg, and apparent oral clearance is 11.6 (± 6.0) and 15.5 (± 5.4) mL/min/kg following doses of 300- and 600-mg, respectively.

Concomitant administration of 300-mg cefdinir capsules with 30 mL Maalox® TC suspension reduces the rate and extent of absorption by approximately 40%. Time to reach Cmax is also prolonged by 1 hour. There are no significant effects on cefdinir pharmacokinetics if the antacid is administered 2 hours before or 2 hours after cefdinir. If antacids are required during OMNICEF therapy, OMNICEF should be taken at least 2 hours before or after the antacid.

OMNICEF is contraindicated in patients with known allergy to the cephalosporin class of antibiotics. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. If CDAD is suspected or confirmed, ongoing antibacterial use not directed against C. Difficile may need to be discontinued.

Some patients can receive cefdinir for UTI , especially if the first- and second-course drugs didn't work. Cefdinir will decrease the level or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by altering intestinal flora. Antibiotics may decrease hormonal contraceptive efficacy. Cefdinir will decrease the level or effect of ethinylestradiol by altering intestinal flora. Levonorgestrel oral/ethinylestradiol/ferrous bisglycinatecefdinir will decrease the level or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by altering intestinal flora.

Famotidine will decrease the level or effect of cefdinir by increasing gastric pH. Applies only to oral form of both agents. Erythromycin stearate decreases effects of cefdinir by pharmacodynamic antagonism. Erythromycin lactobionate decreases effects of cefdinir by pharmacodynamic antagonism. Erythromycin ethylsuccinate decreases effects of cefdinir by pharmacodynamic antagonism. Erythromycin base decreases effects of cefdinir by pharmacodynamic antagonism. Doxycycline decreases effects of cefdinir by pharmacodynamic antagonism.