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Corticosteroids may increase the risks related to infections with any pathogen, including viral, bacterial, fungal, protozoan, or helminth infection. Avoid the use of prednisolone in patients with a fungal infection or bacterial infection that is not adequately controlled with anti-infective agents. Activation of latent disease or exacerbation of intercurrent infection due to pathogens such as Amoeba, Candida, Cryptococcus, Mycobacterium, Nocardia, Pneumocystis, or Toxoplasma can occur in patients receiving systemic corticosteroids. Rule out infection with latent or active amebiasis before initiating corticosteroid therapy in patients who have spent time in the tropics or who have unexplained diarrhea. Use corticosteroids with caution in patients with known or suspected Strongyloides infestation as the immunosuppressive effects may lead to disseminated infection, severe enterocolitis, and sepsis.
They are often used to treat severe skin problems, asthma, and arthritis. Corticosteroids can have side-effects that are very serious as they are very strong medicines. Do not increase or decrease the dosage without consulting your child’s doctor. Certain medications should not be taken with prednisone, and if taken, the child has to be monitored. Consult your doctor before giving your child the following medicines. Your doctor will prescribe the dosage based on your child’s body response and the severity of the condition.
Instruct patients to get immediate medical advice if exposure occurs. If exposed to chickenpox, prophylaxis with varicella-zoster immune globulin may be indicated. If exposed to measles, prophylaxis with pooled intramuscular immunoglobulin may be indicated.
Prednisolone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Based on findings from human and animal studies, corticosteroids can cause fetal harm when administered to a pregnant woman. Published epidemiological studies suggest a small but inconsistent increased risk of orofacial clefts with the systemic use of corticosteroids during the first trimester. Intrauterine growth restriction and decreased birth weight have also been reported with maternal use of corticosteroids during pregnancy; however, the underlying maternal condition may also contribute to these risks. Published animal studies show prednisolone to be teratogenic in rats, rabbits, hamsters, and mice with an increased incidence of cleft palate in offspring. Advise a pregnant woman about the reproductive risk and the potential harm to a fetus.
Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia. Growth and development of infants and children on prolonged corticosteroid therapy should be carefully observed. In patients on corticosteroid therapy subjected to unusual stress, increased dosage of rapidly acting corticosteroids before, during, and after the stressful situation is indicated. Corticosteroids may mask some signs of infection, and new infections may appear during their use.
There they discover that the wrong formulation of prednisolone was dispensed, which was probably responsible for the failure of home therapy. The physician had prescribed the generic for Orapred solution , but the pharmacist had dispensed the bitter-tasting prednisolone base . You are encouraged to report negative side effects of prescription drugs to the FDA. Glucocorticoids such as prednisolone cause profound and varied metabolic effects.
Persons who are on drugs which suppress the immune system are more susceptible to infections than healthy individuals. Chickenpox and measles, for example, can have a more serious or even fatal course in non-immune children or adults on corticosteroids. In such children or adults who have not had these diseases, particular care should be taken to avoid exposure.
In addition, they modify the body's immune responses to diverse stimuli. Naturally occurring glucocorticoids (hydro-cortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs such as prednisolone are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.
Before pouring the medicine into the measuring device, you should check the measurement markings carefully. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake the medicine before use.
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